What is humulene?

Humulene gives many hybrid cannabis strains their earthy scent and offers several therapeutic benefits. This cannabis terpene reduces inflammation, suppresses appetite, and even fights certain types of cancer cells.

The rich terpene profiles of hybrids include humulene and contribute to balanced effects. This blend offers a tailored experience, without indica-induced couch-lock or sativa jitters.

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What are humulene’s effects?

Humulene is a sesquiterpene and an isomer of another terpene, beta-caryophyllene. This means that humulene has the same molecular formula (C15H24) as caryophyllene but a different structural arrangement of atoms, which results in distinct properties and effects. 

In cannabis, hops, sage, ginseng, and some conifers, humulene contributes to the plant's defense mechanisms and aromatic profile. It also helps shape the overall effects and aroma of cannabis strains.

Here are ten ways humulene affects you:

1. Appetite suppression: THC is known for stimulating appetite (the so-called “munchies”), but humulene might have the opposite effect. Some users report feeling less hungry after consuming humulene-rich strains. This could be why certain cannabis varieties don't give you the urge to raid the fridge.
2. Relaxation: Strains high in humulene are relaxing and contribute to a chill, unwinding feeling. While it doesn't directly cause relaxation, such as Delta 9 THC and CBD, it often works with other compounds to promote a mellow mood. 
3. Contribution to the entourage effect: Humulene plays a part in the entourage effect, a phenomenon where cannabinoids, terpenes, and other cannabis compounds work together and enhance each other’s properties and benefits. It may modify how THC and CBD interact with your body's receptors, altering or amplifying their effects.
4. Anti-inflammatory effects: Humulene calms your body's inflammatory response. These properties could help people dealing with inflammatory diseases and ease symptoms in everything from arthritis to gut issues.
5. Pain relief: Working alongside other cannabis compounds, humulene contributes to the pain-reducing effects of cannabis. 
6. Sedation: Humulene contributes to a gentle, calming effect that helps with relaxation and sleep. If you're looking to unwind after a long day or ease into a restful night, strains rich in humulene are what you need.
7. Mood: Humulene may contribute to a balanced, positive mood. While not euphoric like THC, it works with other cannabis compounds to promote a sense of contentment and clarity. Humulene can ease stress without cognitive impairment.
8. Antibacterial potential: Some studies suggest humulene has antibacterial properties. It damages bacterial cell membranes and boosts the effects of other antibacterial compounds.
9. Anticancer properties: Humulene may inhibit tumor growth in some cancer cells. A 2022 Chinese study shows that, in synergy with another minor terpene called sclareol, humulene can fight pancreatic cancer cells by triggering cell death and stopping cancer spread. They also hinder the development of key proteins in cancer cells, which slows tumor growth in lab tests and live animals. 
10. Allergy relief: Some research points to humulene having antiallergic properties. It fights stomach irritation and allergic reactions by blocking histamine release from mast cells and ramping up protective factors in your gut lining.

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What is the flavor profile of humulene?

You can recognize humulene for its earthy and woody aroma. You'll likely notice a subtle bitterness upfront, followed by warm, spicy notes that linger on your tongue. It's similar to the flavor you might get from chewing on a pine needle or a hop flower. 

There's also a slight peppery quality to it, almost like a mild version of black pepper, but not as sharp. Some people pick up hints of a herbaceous, basil taste. The overall effect is a robust, natural flavor that's not overpowering but noticeable.

What does humulene smell like?

When you take a whiff of humulene, you'll likely be reminded of a forest after rainfall. It has a strong, pine scent, similar to fresh hops or sage. There's also a spicy smell, somewhat like a mild black pepper or coriander. 

The overall effect is a rich, natural fragrance that's grounding and refreshing. This distinctive aroma contributes significantly to the complex scent profile of cannabis strains. 

Cannabis strains high in humulene

Humulene is found in sativa and indica strains, but it’s one of the most abundant terpenes in hybrid varieties. Hybrids offer a balanced experience because they blend the best traits of both sativa and indica, boosted by the therapeutic benefits of humulene for a well-rounded experience. 

Here are six hybrid cannabis strains with a high humulene content:

1. GSC (formerly Girl Scout Cookies)
2. Gelato
3. Sour Diesel
4. White Widow
5. Sherbet
6. OG Kush

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Potential side effects of humulene

Humulene is safe when consumed in typical amounts found in foods and cannabis, but it can cause side effects in high concentrations. These side effects are mild and can be different from person to person. 

Here are some potential side effects:

• Skin irritation (when applied topically)
• Allergic reactions in sensitive individuals
• Gastrointestinal discomfort
• Headaches
• Dizziness
• Nausea
• Interaction with certain medications

Always consult a healthcare professional before using products high in humulene, especially if you have existing health conditions or are taking medications.

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Resources

Chassagne, F., Samarakoon, T., Porras, G., Lyles, J. T., Dettweiler, M., Marquez, L., Salam, A. M., Shabih, S., Farrokhi, D. R., & Quave, C. L. (2021). A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective. Frontiers in Pharmacology, 11, 586548. https://doi.org/10.3389/fphar.2020.586548

Kang, Y., Wang, X., Wei, X., Li, D., Gan, L., Jin, J., Wu, R., Wu, P., Sheng, Z., Zhang, K., Goodin, S., Xu, X., & Zheng, X. (2022). Synergistic inhibitory effect of α-humulene and sclareol on human pancreatic cancer cells. Journal of Functional Foods, 89, 104958. https://doi.org/10.1016/j.jff.2022.104958

Yeo, D., Hwang, S., Song, Y., & Lee, H. (2021). Humulene Inhibits Acute Gastric Mucosal Injury by Enhancing Mucosal Integrity. Antioxidants, 10(5), 761. https://doi.org/10.3390/antiox10050761

Further reading

Are hybrids uppers or downers?

Our THC gummies that give you energy

THC drinks vs edibles

How to make THC beverages

How does the hybrid weed trigger the entourage effect?

Indica vs sativa vs hybrid: what you need to know

Side effects of hybrid cannabis strains

What is hybrid weed good for?

The best THC microdosing amounts

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