What are the side effects of hybrid weed?

May 27, 2024The nama Team
What are the side effects of hybrid weed? by namaCBD

Hybrid cannabis strains offer a plethora of therapeutic and recreational benefits, but if you overindulge, you may experience some side effects. 

Even if you take an excessive dose of hybrid weed, the side effects, while potentially uncomfortable, are not life-threatening. To avoid unpleasant experiences, stick to microdosing practices, go slow, and listen to your body's reactions.

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The potential of hybrid cannabis for side effects

Hybrid cannabis strains can cause side effects, but they are dose-dependent. When you keep your consumption in check, you're less likely to experience unwanted effects. If you indulge in a dose higher than your body can handle, that's when you may start to experience unpleasant side effects.

When you consume lower, moderate doses, hybrid cannabis provides therapeutic benefits without causing significant side effects. You experience a balanced combination of physical relaxation and mental stimulation, which can alleviate stress, anxiety, and chronic pain while promoting focus and creativity. These therapeutic effects are more likely to occur when you tailor the dose to your personal tolerance level.

Higher doses of hybrid cannabis may overwhelm the user and lead to unpleasant outcomes. 

What are the side effects of too much hybrids?

The side effects of too much hybrid cannabis are not life-threatening, but they can be uncomfortable and may temporarily impair normal functioning. They include:

  • Intense anxiety and paranoia
  • Rapid heart rate and palpitations
  • Dizziness and nausea
  • Dry mouth and eyes
  • Impaired coordination and judgment
  • Confusion and disorientation
  • Extreme drowsiness and fatigue
  • Short-term memory impairment
  • Heightened sensory perception
  • Possible hallucinations or delusions
  • Headaches
  • Respiratory irritation (if smoked)
  • Increased appetite and potential overeating
  • Difficulty concentrating or completing tasks
  • Mood swings or irritability

Everyone's tolerance to hybrid cannabis is different, so what might be a perfect dose for one person could cause anxiety or paranoia in another. 

What factors influence the side effects?

The factors that influence the likelihood and severity of side effects are:

  1. A person’s tolerance to cannabis
  2. The way cannabis is consumed
  3. Strain-specific effects
  4. Interactions with other substances
  5. Psychological and environmental factors
  6. A person’s overall health
  7. How frequently cannabis is consumed

Individual tolerance and sensitivity

Everyone's endocannabinoid system (ECS) is unique. Your ECS regulates mood, appetite, pain sensation, memory, and other important physiological processes. The ECS interacts with cannabis compounds differently in each person, which explains why people have diverse experiences and side effects. Those with lower tolerance may experience side effects even at lower doses, while others may need an excessive dose to feel any effects.

Cannabis consumption method

Consumption methods of hybrid cannabis are one of the most important factors for the onset, intensity, and duration of effects. 

  • Smoking and vaping produce more immediate and potent effects. The cannabinoids are rapidly absorbed into the bloodstream through the lungs, increasing the risk of adverse reactions, especially if you consume too much too quickly. 
  • Edibles have a slower onset time, between 30 minutes and 2 hours. They must be processed by the digestive system before the Delta 9 THC in them hits your bloodstream. Their effects are longer-lasting and sustained, and produce fewer adverse effects when you stick to recommended doses. 
  • Many people new to edibles might think they're not working because of the delayed onset, so they are tempted to increase their dose. This can potentially lead to overconsumption and unpleasant side effects when the effects finally kick in.
  • Sublingual tinctures and oils fall somewhere in between, with a relatively quick onset (between 10 and 30 minutes), but a more gradual intensity than inhaled cannabis. 

The quicker the onset of effects, the higher the probability of side effects. Our THC gummies and cannabis-infused mixers are much safer than inhalation methods. Their onset time differs (THC drinks are quicker to produce effects than gummies), but both methods offer a sustained and generally safer cannabis experience.

Strain-specific effects

The specific genetic makeup of a hybrid strain can influence the type and intensity of side effects experienced. Here's how:

  • Hybrid strains with a higher proportion of indica genetics produce more relaxing, sedative effects that may cause drowsiness, couch-lock, and potential dizziness if consumed in excess. 
  • Hybrids with a higher sativa content are more likely to produce cerebral, energetic effects that could potentially lead to anxiety or paranoia in high doses.
  • The ratio of tetrahydrocannabinol (THC) to cannabidiol (CBD) in a hybrid strain can impact the likelihood and severity of side effects. THC is the primary psychoactive compound responsible for the "high" and potential psychoactive effects. With its anxiolytic and antipsychotic properties, CBD counteracts some of these side effects associated with THC. Strains with a higher THC-to-CBD ratio can cause adverse reactions, while those with a more balanced ratio or higher CBD content may be less likely to do so.
  • Terpenes from the cannabis plant contribute to the strain's unique scent, flavor, and effects. Terpene limonene has uplifting and mood-enhancing properties, but it may also increase the risk of anxiety or restlessness in some users. Terpene myrcene has sedative and relaxing effects that could potentially cause drowsiness or lethargy when consumed in high amounts.
  • Hybrid cannabis strains contain minor cannabinoids such as cannabigerol (CBG), cannabinol (CBN), and tetrahydrocannabivarin (THCV). Each one has its own unique effects and potential side effects. 

Interactions with other substances

When you mix hybrid cannabis with alcohol or certain medications, you can amplify or change the effects you experience, making them stronger or different than usual. This combination increases the chances of experiencing unpleasant reactions you might not have had otherwise. Avoid combining cannabis with other substances; it’s risky and often leads to unexpected side effects.

Psychological and environmental factors

When consuming cannabis, your mindset and emotional state are more important than you think. Cannabis can amplify or distort your existing emotional state and thought patterns. If you're feeling stressed, anxious, or in an uncomfortable environment, it can heighten your chances of experiencing negative side effects. An unfamiliar or stressful setting can make you feel more on edge or uneasy, potentially exacerbating negative effects.

The user’s overall health

People with pre-existing health conditions, such as cardiovascular issues or mental health disorders, may be more prone to experiencing certain side effects from hybrid cannabis. For example, those with heart conditions have a higher risk of increased heart rate or blood pressure. Those with anxiety disorders may experience heightened anxiety or panic symptoms.

Frequency of use

Regular, long-term, and heavy use of hybrid cannabis increases your tolerance. You may need to consume more to achieve the same effects. As tolerance builds up, you may be less likely to experience certain side effects, such as intoxication or impairment. Chronic heavy use can also lead to dependence and withdrawal symptoms when you stop using cannabis.

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Can cannabis hybrids have long-term effects?

The effects of cannabis are temporary and pass after a few hours as the active compounds metabolize and leave your system. Regular heavy use of cannabis, regardless of the strain, may produce long-term effects. 

French researchers explain that frequent and prolonged use of cannabis can lead to chronic effects such as:

  • Mood disorders
  • Exacerbation of psychotic disorders in vulnerable people
  • Cannabis use disorders
  • Withdrawal syndrome
  • Neurocognitive impairments
  • Cardiovascular and respiratory diseases

Harvard scholars reveal that long-term, heavy cannabis use (several years or more, at least 4 times per week) is associated with cognitive impairments such as declining IQ and deficits in learning, memory, processing speed, and motivation. 

At low, therapeutic amounts, cannabis has the potential to boost cognition, improve focus and memory, and even aid in the creation of new neurons (neurogenesis).

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How much cannabis is safe to consume?

Whether you’re using cannabis for recreational or medical purposes, microdosing cannabis is the way to go. This method helps to minimize potential side effects while still providing the desired benefits. 

Here's a guide to understanding safe consumption levels:

  • Amounts between 2–5mg of THC are considered a microdose. These amounts are great for beginners or those looking for mild effects.
  • Doses of 5–10mg of THC are lower amounts, suitable for regular users seeking mild to moderate effects.
  • Amounts between 10–25mg of THC can produce side effects for most users.
  • Higher doses of 25–50mg of THC can lead to more serious side effects, such as severe anxiety, paranoia, and impaired motor skills.
  • Doses of 50–100mg of THC are extremely high and can result in heavy side effects, including severe temporary cognitive impairment, hallucinations, and potentially harmful physical effects.

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How to avoid side effects

You can take precautions to minimize the chances of experiencing adverse reactions. Here’s how to ensure a more pleasant and manageable hybrid strain experience:

  1. Start low and go slow. Begin with a low dose, especially if you're new to cannabis or trying a particularly potent strain. Gradually increase the amount until you achieve the desired effects.
  2. Choose the right strain. Different cannabis strains produce different effects. Some may be more likely to cause certain side effects than others. 
  3. Consume in a safe and comfortable environment. Your surroundings can influence your experience, so try to consume cannabis in a familiar, relaxed, and comfortable setting where you feel safe and at ease. Avoid stressful or unfamiliar environments.
  4. Stay hydrated and nourished. Cannabis can cause dry mouth and dehydration, which can exacerbate potential side effects. Make sure to stay hydrated and drink plenty of water before, during, and after consuming cannabis. Having something to eat can also mitigate potential side effects.
  5. Avoid combining with other substances. In combination with alcohol, prescription medications, or other drugs, cannabis can produce unpredictable side effects. Avoid these combinations.
  6. Know your limits and take breaks. If you're experiencing unpleasant side effects, don't try to push through them. Instead, take a break and allow the effects to subside. 
  7. Choose the best consumption method. Low-dose gummies and THC-infused drinks are much safer than inhaling cannabis, as they allow for more precise dosing and reduce the risk of respiratory issues. Edibles provide a longer-lasting and more controlled experience, making it easier to manage your intake and avoid potential side effects.

Low-dose edibles are what we do best. We infuse our gummies with organic fruit and hemp-derived cannabis compounds to create a delicious, natural product that provides a consistent and enjoyable experience every time. 

Indulge in our delicious Relax Plus gummies with only 5 milligrams of THC per serving. These delicious edibles are perfect for unwinding after a long day, offering a gentle, calming effect without overwhelming side effects.

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Try our low-dose hybrid edibles

If you're looking to buy the best Delta 9 edibles, you're in the right place. At nama™, we pride ourselves on offering premium edibles that contain non-GMO American hemp extract and real fruit flavors. Each batch undergoes rigorous third-party lab testing to ensure top-notch quality and potency. We source our hemp from small, dedicated farms in Colorado and New Jersey, guaranteeing our products are 100% American and organic.

Our hybrid gummies and drinks provide the perfect balance of sativa strains and indica genetics that offer relaxation and energizing effects without clouding your experience. 

All our cannabis edibles are federally legal, so you can order online and have them delivered anywhere in 48 US states. (Read more about the state-by-state legality of Delta 9 THC.)

Further reading

How to choose between sativa and indica

Is 10mg of THC in an edible too much for a beginner?

What are the main ingredients of Buzz Drops™?

What strain can help my anxiety and OCD?

What’s the difference between hybrid and sativa?

Do indica and hybrid strains produce similar effects?

Are sativa or indica better at managing pain?

Hybrid weed side effects FAQ

Hybrid cannabis strains produce their effects by combining the properties of sativa and indica parent strains. The specific effects depend on the terpene profile and chemical composition of the particular hybrid strain. Common effects include:

  • Uplifting cerebral effects
  • Balanced hybrid effects with both energizing and calming experiences
  • Stress relief
  • Pain relief
  • Potential medical benefits

Many hybrid strains may alleviate symptoms of depression and anxiety because of their balanced effects. Hybrids provide an uplifting mood boost along with stress relief. Some hybrid sativa strains could potentially increase anxiety in some sensitive people. 

If you’re struggling with anxiety, depression, or other mood disorders, choose the strain that’s higher in anxiolytic properties so it doesn’t exacerbate your mental conditions. Start with a low dose and gradually increase. 

While sativa strains are generally associated with more cerebral and focusing effects, some well-balanced hybrid strains may also aid concentration and focus. These effects depend on their specific terpene profile and chemical compounds. At excessive doses, cannabis can impair cognitive function in some people, so stick to low, therapeutic amounts.

While extremely rare, there are still some pure sativa cannabis strains available. They are believed to originate from landrace equatorial sativa varieties. Landrace equatorial sativa varieties are pure, indigenous sativa strains from equatorial regions without crossbreeding. These strains produce invigorating, cerebral, and energizing effects. Some of the most renowned pure sativa strains include:

  • Sour Diesel
  • Super Lemon Haze
  • Green Crack
  • Maui Wowie

Most modern strains are hybrids containing varying degrees of sativa and indica genetics.

Some people with ADHD report that certain sativa-dominant or balanced hybrid strains with uplifting and focusing effects may alleviate ADHD symptoms. These strains improve focus and concentration while promoting a calm, attentive state of mind. The uplifting and motivating qualities of sativas, combined with the relaxing indica effects in balanced hybrids, could counteract symptoms such as inattentiveness, hyperactivity, and restlessness associated with ADHD.

The experience of a hybrid high depends on the specific strain and its chemical profile. A hybrid strain may produce a combination of cerebral, uplifting effects from the sativa parent, along with the relaxing, calming influences of the indica parent. The overall experience could range from a balanced, functional high to a more sedating or energizing effect, depending on the hybrid's dominant traits.

There is no single "best" strain for mood improvement because people respond differently to different cannabis varieties. Many users report that hybrid strains with balanced effects or a slightly sativa-dominant profile can provide an uplifting mood boost while relieving stress and pain. Strains with terpenes such as limonene are associated with uplifting effects, and they may also improve mood.

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Karila L, Roux P, Rolland B, Benyamina A, Reynaud M, Aubin HJ, Lançon C. Acute and long-term effects of cannabis use: a review. Curr Pharm Des. 2014;20(25):4112-8. doi: 10.2174/13816128113199990620. PMID: 24001294.

Mhs, K. H. M. (2022, June 14). Cognitive effects in midlife of long-term cannabis use. Harvard Health. https://www.health.harvard.edu/blog/cognitive-effects-of-long-term-cannabis-use-in-midlife-202206142760

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