Hybrid cannabis for unlocking the entourage effect

Jun 21, 2024The nama Team
Hybrid cannabis for unlocking the entourage effect-namaCBD

In the entourage effect, cannabis compounds work together synergistically to amplify the benefits. Hybrid cannabis strains combine sativa and indica properties to enhance the entourage effect and deliver a wider range of therapeutic benefits.

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What does the entourage effect feel like?

The entourage effect is not a specific feeling that you can immediately perceive. Rather, the entourage effect is a culmination of the beneficial effects you start to notice over time when you consume multiple cannabis compounds together. 

Components such as cannabinoids, terpenes, and flavonoids. work synergistically to enhance the overall therapeutic potential of the cannabis plant. Unlike the immediate psychoactive effects of THC or the rapid onset of relaxation from CBD, the entourage effect is more subtle and takes time to develop. 

When you consistently use cannabis products that amplify the entourage effect, you may begin to notice the positive impacts after a few weeks to a month. Some common benefits associated with the entourage effect include:

  • Reduced anxiety and stress levels
  • Improved sleep quality and duration
  • Better mood and emotional balance
  • Enhanced focus and mental clarity
  • More effective pain management
  • Increased appetite
  • Improved digestive health
  • Potential anti-cancer mechanisms

The entourage effect is highly individualized. Some people may notice significant improvements in their overall well-being after a week or two, while others may experience more subtle changes after two months. To maximize the effects of the entourage effect, choose hybrid cannabis products that combine indica and sativa cannabis varieties in balanced ratios. 

Full-spectrum cannabis products are ideal for triggering the entourage effect. Try our microdosed gummies or low-dose cannabis beverages and experience the therapeutic effects of THC, CBD, terpenes, and other cannabis compounds working together to enhance your cannabis experience.

Benefits of hybrid weed for the entourage effect

Hybrid cannabis strains offer a world of benefits for both medicinal and recreational users. No need to explain why—it’s thanks to their unique ability to harness the power of the entourage effect. 

Here are some of the key benefits of hybrid cannabis for the entourage effect:

  1. Hybrid strains offer a more well-rounded experience, combining the energizing and uplifting qualities of sativas with the relaxing and pain-relieving properties of indicas.
  2. With a diverse range of hybrid strains available, users can tailor their cannabis experience to suit their specific needs and preferences.
  3. The entourage effect in hybrid strains can amplify the medicinal properties of cannabis, providing more effective relief for chronic pain, anxiety, depression, and insomnia.
  4. Hybrid strains can elevate mood, reduce stress and anxiety, and promote a sense of overall well-being.
  5. Some hybrid strains can enhance creative thinking, boost motivation, and improve focus. Those who’re pursuing artistic or productive tasks often choose a balanced hybrid strain.  
  6. The synergistic interaction of cannabinoids and terpenes in hybrid strains provides more comprehensive and efficient pain relief than single-compound medications.
  7. By offering a balance of effects, hybrid strains mitigate some of the potential side effects associated with high-THC or high-CBD strains, such as anxiety or drowsiness.
  8. Hybrid strains offer a fun and engaging recreational experience, with a wide range of flavors, aromas, and effects to explore and enjoy.

How does hybrid weed amplify the entourage effect?

Hybrid cannabis strains combine the unique properties of indica and sativa to enhance the entourage effect. At the heart of this synergistic interaction is the endocannabinoid system (ECS).

The role of the endocannabinoid system

The endocannabinoid system is a complex network of receptors called endocannabinoids, signals, and enzymes that help regulate physiological processes, such as mood, pain perception, appetite, and sleep. The ECS has two main types of cannabinoid receptors: CB1 and CB2. They play crucial roles in mediating the effects of cannabinoids and are located in different parts of the body.

  • CB1 receptors are primarily found in the central nervous system (the brain and spinal cord). They are one of the most abundant receptor types in the brain, particularly in regions associated with memory, cognition, mood, pain perception, and motor control. CB1 receptors are also found in lower concentrations in various peripheral tissues, such as the liver, thyroid, uterus, and bones, where they help regulate physiological processes like metabolism and bone growth.
  • CB2 receptors are more abundant in the peripheral nervous system and the immune system. They are found in immune cells, such as B cells, T cells, and macrophages, as well as in the spleen, tonsils, and gastrointestinal tract where they regulate immune function and inflammation. CB2 receptors are also found in lower concentrations in the central nervous system, particularly in microglial cells, which are involved in immune surveillance and inflammatory responses in the brain.

Cannabis interacts with both CB1 and CB2 receptors to produce their effects. Delta 9 THC binds directly to CB1 receptors and produces its well-known psychoactive effects when consumed at large doses. Cannabidiol (CBD) has a more indirect interaction with the ECS. It modulates the effects of other cannabinoids (mainly THC) and influences the production of endocannabinoids.

Instead of directly binding with CB1 and CB2 receptors, CBD seems to downregulate them in the presence of THC. In other words, when CBD and THC are taken together, CBD regulates how THC interacts with CB1 and CB2 receptors (Vuckovic, et. al.)

In the entourage effect, cannabis compounds work together to interact with both CB1 and CB2 receptors simultaneously in different ways. This synergistic interaction produces a more balanced and comprehensive range of effects compared to single-compound products.

Hybrid cannabis compounds involved in the entourage effect

Hybrid weed contains many types of compounds that create the entourage effect together. The main ones are cannabinoids and terpenes. Here’s a more detailed list of all cannabis compounds found in hybrid strains that produce the entourage effect:

  1. Cannabinoids
  2. THC (tetrahydrocannabinol) is the main psychoactive compound in cannabis, known for producing the "high" sensation and providing pain relief, appetite stimulation, and relaxation.
  3. CBD is a non-psychoactive cannabinoid with potent anti-inflammatory, anxiolytic, and analgesic properties. It’s often used to alleviate symptoms of anxiety, epilepsy, and chronic pain.
  4. CBG (cannabigerol) is a minor cannabinoid that has shown potential as an antibacterial, anti-inflammatory, and neuroprotective agent. It may be beneficial for people with glaucoma, inflammatory bowel disease, and Huntington's disease.
  5. CBC (cannabichromene) is another non-psychoactive cannabinoid with the potential to reduce inflammation, relieve depression, and soothe pain.
  6. CBN (cannabinol) is a mildly psychoactive cannabinoid that is produced when THC ages. It’s known for its sedative effects and potential as an anticonvulsant and anti-inflammatory agent.
  7. THCV (tetrahydrocannabivarin) is a minor cannabinoid that has shown potential as an appetite suppressant, antidiabetic, and neuroprotective agent.
  8. CBDV (cannabidivarin) has the potential as an anticonvulsant and anti-inflammatory agent. Its possible applications include treating epilepsy and autism spectrum disorder.
  9. Delta 8 THC is an isomer of THC with similar psychoactive effects but is less potent. Delta 8 is known for its antiemetic, anxiolytic, and analgesic properties.
  10. Terpenes are aromatic compounds found in cannabis and other plants that contribute to the distinctive flavors and aromas of different strains. The rich terpene profile of hybrid strains adds to their therapeutic benefits.
  11. Other compounds
  12. Flavonoids are a class of plant pigments that have antioxidant, anti-inflammatory, and neuroprotective properties.
  13. Fatty acids show potential as anti-inflammatory agents. They may help regulate the endocannabinoid system.
  14. Phenolic compounds are a class of antioxidants found in cannabis that may contribute to its anti-inflammatory and neuroprotective effects.
  15. Alkaloids are nitrogen-containing compounds found in small amounts in cannabis with diverse pharmacological effects.
  16. Anthocyanins are water-soluble pigments found in some hybrid cannabis strains that have antioxidant and anti-inflammatory properties.

Hybrid weed strains are carefully bred to contain specific ratios of cannabinoids and terpenes, tailored to produce desired effects. They all add to the overall therapeutic properties and effect hybrid strains produce. 

For example, terpenes can enhance or modulate the effects of cannabinoids by interacting with the ECS receptors or influencing the absorption and distribution of cannabinoids in the body. For example, terpene myrcene has sedative properties and can enhance the relaxing effects of indica-dominant hybrid strains, while limonene is associated with mood elevation and can contribute to the uplifting effects of sativa-dominant strains.

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The best weed strains for the entourage effect

Hybrid weed strains are crafted by crossing indica and sativa varieties, offering a more diverse range of cannabinoid and terpene profiles for the ultimate entourage effect. Hybrid strains can be categorized into three main types: sativa-dominant, indica-dominant, and balanced hybrids. 

Indica-dominant strains for the entourage effect

Indica-dominant hybrid strains are the go-to choice for those seeking a powerful entourage effect that prioritizes relaxation, stress relief, and pain management. With higher ratios of CBD to THC, these strains work in harmony with terpenes such as myrcene, linalool, and caryophyllene to create a soothing symphony of therapeutic benefits. 

The entourage effect in indica-dominant hybrids is characterized by a deep sense of calm, full-body relaxation, and improved sleep quality. Those who’re looking to unwind after a long day or manage chronic pain often choose indica-dominant hybrids. While the sedating nature of these strains may cause drowsiness in some users, for many, it's a welcome invitation to a peaceful, restorative experience. 

Here are five of the most popular indica-dominant strains that are perfect for producing a calming, pain-relieving, and stress-melting entourage effect:

  1. Granddaddy Purple
  2. Northern Lights
  3. Blueberry
  4. OG Kush
  5. Purple Punch

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Sativa-dominant strains for the entourage effect

Sativa-dominant hybrid strains are the right choice for those seeking an energizing and uplifting entourage effect that enhances focus, creativity, and motivation. These strains feature higher ratios of THC to CBD and are enriched with terpenes such as limonene, pinene, and terpinolene, which work synergistically to create a stimulating and mood-enhancing experience. 

When combined with THC and other cannabinoids, these terpenes reduce stress and anxiety while promoting a clear-headed and productive high. Higher THC content would normally lead to anxiety, paranoia, or other side effects in beginners or those sensitive to cannabis—but the synergistic effects of THC with CBD and other soothing compounds ensure a balanced experience. 

Here are five of the best sativa-dominant hybrid strains for producing an energizing, creative, and stress-relieving entourage effect:

  1. Green Crack
  2. Sour Diesel
  3. Jack Herer
  4. Super Silver Haze
  5. Strawberry Cough

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Why choose a balanced hybrid strain?

Sativa-dominant or indica-dominant hybrids may sometimes lead to unbalanced experiences, where one set of effects overpowers the other. For example, the high THC content in some sativa-dominant strains can make some people feel anxious or paranoid, while the sedating effects of indica-dominant strains may cause excessive drowsiness or lethargy. Balanced hybrid strains offer the best of both worlds by combining the energizing and uplifting qualities of sativa-dominant strains with the relaxing and pain-relieving properties of indica-dominant strains. 

Balanced hybrids reduce anxiety, improve mood, alleviate pain, and enhance overall well-being without the overwhelming dominance of one particular effect. The synergistic interaction of THC, CBD, and terpenes work together to provide a full spectrum of therapeutic benefits. The complex interplay of terpenes such as myrcene, limonene, pinene, and caryophyllene create a more nuanced and tailored experience, catering to the specific needs and preferences of each individual user. This balance is crucial for those who want to maintain a clear head while still enjoying the relaxing and soothing properties of cannabis. 

Here are five of the most popular balanced hybrid strains that produce an exceptional entourage effect:

  1. Blue Dream
  2. Gelato
  3. Wedding Cake
  4. Gorilla Glue #4
  5. Pineapple Express

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Is the entourage effect real?

The question of the entourage effect has been the subject of much debate and skepticism within the cannabis community. A growing body of scientific evidence supports the existence and significance of this cannabis synergy. Studies have demonstrated that the synergistic interactions between cannabinoids and terpenes can enhance the therapeutic potential of cannabis, providing a biological basis for the entourage effect. 

Ferber, et. al. postulate that the interaction of cannabinoids with the endocannabinoid system is a clear evidence of the effects and efficacy of the entourage effect. The way THC, CBD, terpenes, and other compounds in cannabis influence CB1 and CB2 receptors demonstrates how the synergistic interplay of these compounds can produce a wide range of therapeutic benefits that are greater than the sum of their individual effects.

Feber et. al. also suggest that the entourage effect may easily be proven by looking at the way terpenes influence the binding affinity of cannabinoids to receptors, modulate the absorption and metabolism of cannabinoids, and contribute to the overall therapeutic effect through their own unique properties. 

We’ve gathered several important pieces of evidence that testify to the potent and very real effects of the entourage effect

  • A 2018 Spanish study on breast cancer found that a cannabis extract worked better than pure THC for treating tumors. The researchers think this is because the extract contained small amounts of other cannabinoids such as CBG and THCA, which joined forces with THC to produce a stronger anti-cancer effect.
  • Johnson, et. al. showed that a cannabis extract containing both THC and CBD was more effective in treating pain in cancer patients than a pure THC extract. This is a clear indication of the synergistic benefits of combining cannabinoids.
  • A 2015 study found that many pediatric epilepsy patients who used CBD-rich cannabis oils containing small amounts of other compounds such as THC and THCA experienced significant reductions in seizure frequency and severity. The author suggests this enhanced effect compared to pure CBD is likely because of the "entourage effect." 
  • La Vigne, et. al. shed light on the evidence that Cannabis sativa terpenes can enhance the activity of cannabinoids. The terpenes α-humulene, β-pinene, linalool, and geraniol induced cannabimimetic effects in mice similar to the cannabinoid WIN55,212-2. These effects were mediated by the CB1 receptor and adenosine A2A receptor. When combined with WIN55,212-2, the terpenes selectively enhanced certain cannabinoid-induced behaviors, demonstrating terpene-cannabinoid synergistic interactions that contribute to the entourage effect.

While isolated compounds such as pure THC or CBD may have their limitations, the entourage effect highlights the potential benefits of whole-plant extracts. Current evidence strongly suggests that the entourage effect is a real and significant aspect of cannabis therapy.

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Indulge in the harmonious symphony of cannabinoids and terpenes, unlocking the full potential of hybrid cannabis strains. Experience the entourage effect in its purest form, a delightfully sweet path to holistic wellness. 

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Hybrid weed FAQ

Tetrahydrocannabinolic acid, or THCA, is present in both indica and sativa strains. It's a non-psychoactive cannabinoid that converts to THC when heated. THCA itself is not categorized as indica or sativa; those classifications refer to the different varieties or strains of the cannabis plant. The levels of THCA varies between indica, sativa and hybrid strains, but its presence transcends these botanical distinctions. What determines whether a strain is indica or sativa depends more on the plant's genetic makeup and physical characteristics.

For maximizing the entourage effect, full-spectrum and broad-spectrum CBD products are the best options. These products contain a blend of cannabinoids, terpenes, and other organic compounds found in cannabis. Full-spectrum CBD includes THC, while broad-spectrum CBD excludes THC, but it retains other beneficial compounds. This blend creates a synergistic effect, enhancing the potential medical benefits than CBD isolate, which only contains cannabidiol.

Terpenes play a crucial role in affecting the high experienced from cannabis. These organic compounds interact with cannabinoids to influence the overall effects on the user. For instance, myrcene can enhance the sedative and pain-relief properties, providing calming effects, while terpene limonene may uplift mood and reduce anxiety, offering more energizing effects. This interaction, known as the entourage effect, underscores the importance of terpenes in shaping the distinct effects of cannabis strains.

Hybrid weed provides a balanced high rather than necessarily a stronger one. Hybrids combine the characteristics of both indica and sativa, resulting in varied effects depending on the specific hybrid’s cannabinoid profile and terpene composition. Some hybrids might offer a potent psychoactive experience, combining the relaxing effects of indica with the energizing effects of sativa, while others may provide a more moderate, balanced high, suitable for different activities and needs.

Hybrid weed is for maintaining focus, especially strains with a sativa-dominant profile. These strains often combine the uplifting and energizing effects of sativa with the calming and relaxing benefits of indica. This balanced effect improves concentration and mental clarity without causing excessive sedation or overstimulation. This is why hybrids are ideal for tasks requiring sustained focus and creativity.

Hybrid weed offers versatile and balanced effects. By combining traits from both indica and sativa strains, hybrids are tailored to meet a wide range of needs, from pain relief and relaxation to mental clarity and energy. The varied chemical composition, including a blend of cannabinoids and terpenes, makes hybrid strains suitable for both recreational and medicinal cannabis users.

Strains with a high THC content and a rich cannabinoid profile, such as Gorilla Glue #4 and Blue Dream, provide a long-lasting high. These strains contain a potent combination of THC, other minor cannabinoids, and abundant terpenes that contribute to their prolonged effects. The enduring subtle psychoactive experience makes these strains popular among users looking for extended relief or recreational enjoyment.

Sativa-dominant hybrid strains are renowned for their energizing effects. Strains such as Green Crack and Durban Poison boost energy levels, enhance creativity, and improve focus. These strains have a distinct chemical composition rich in energizing terpenes such as limonene and pinene, making them ideal for daytime use and activities requiring mental and physical stimulation.

There is no definitive evidence directly linking cannabis use to hair loss. Factors such as stress, hormonal changes, and lifestyle habits might contribute to hair loss. Microdosed gummies could help alleviate stress and regulate hormones, which in turn may aid in reducing hair loss. The balanced combination of cannabinoids and terpenes in our entourage effect gummies may provide a natural way to promote a calmer state and support the body's homeostasis.

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Vučković, S., Srebro, D., Vujović, K. S., Vučetić, E., & Prostran, M. (2018). Cannabinoids and Pain: New Insights From Old Molecules. Frontiers in Pharmacology, 9. https://doi.org/10.3389/fphar.2018.01259

Ferber, S. G., Namdar, D., Hen-Shoval, D., Eger, G., Koltai, H., Shoval, G., Shbiro, L., & Weller, A. (2020). The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders. Current Neuropharmacology, 18(2), 87-96. https://doi.org/10.2174/1570159X17666190903103923

Blasco-Benito S, Seijo-Vila M, Caro-Villalobos M, Tundidor I, Andradas C, García-Taboada E, Wade J, Smith S, Guzmán M, Pérez-Gómez E, Gordon M, Sánchez C. Appraising the "entourage effect": Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer. Biochem Pharmacol. 2018 Nov;157:285-293. doi: 10.1016/j.bcp.2018.06.025. Epub 2018 Jun 27. PMID: 29940172.

Johnson JR, Burnell-Nugent M, Lossignol D, Ganae-Motan ED, Potts R, Fallon MT. Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain. J Pain Symptom Manage. 2010 Feb;39(2):167-79. doi: 10.1016/j.jpainsymman.2009.06.008. Epub 2009 Nov 5. PMID: 19896326.

LaVigne, J. E., Hecksel, R., Keresztes, A., & Streicher, J. M. (2021). Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity. Scientific Reports, 11(1), 1-15. https://doi.org/10.1038/s41598-021-87740-8

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