What is CBN?
Cannabinol (CBN) is a minor cannabinoid found in cannabis plants. CBN is derived from the degradation of THC. As THC is exposed to air and heat over time, some percentage turns into CBN.
There are many potential benefits of CBN, such as improved sleep, appetite stimulation, anxiety reduction, and anti-inflammatory effects. (Read more about what CBN is good for.)
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How Does CBN Help with Inflammation?
CBN works with the body through the endocannabinoid system (ECS). This is a cell-signaling system of neurotransmitters and receptors (CB1 and CB2). The ECS helps regulate physiological processes such as pain and mood perception, immune responses, memory and learning, appetite, and sleep.
The neurotransmitters act as messengers, sending signals throughout the body. The receptors receive these signals and respond where necessary. CB1 receptors are primarily found in the central nervous system, including the brain and spinal cord. CB2 receptors are mainly found in the peripheral nervous system, immune cells, and peripheral tissues. Research suggests that both CB1 and CB2 receptors are involved in inflammatory hypersensitivity, which can be therapeutic during inflammatory pain.
As an alternative to other anti-inflammatory drugs, CBN products can reduce inflammation and alleviate pain. The potential benefits of CBN for inflammation occur through the ECS. CBN has a binding effect on the CB1 and CB2 receptors, like neurotransmitters do. Once CBN binds to the receptors, it can help regulate certain activities in the body.
Studies have shown that cannabinoids can suppress the inflammatory response and promote immunoregulation. CBN shows potential for interacting with the CB2 receptors that are primarily found in immune cells. When the CB2 receptors are activated by CBN, it can help regulate the immune response and mitigate inflammation.
Inflammation is often accompanied by pain, and CBN may offer pain relief. When CBN interacts with the CB1 receptors, it shows the potential for having analgesic properties that relieve chronic pain. This offers additional relief from inflammatory health conditions and helps those with chronic muscle pain.
Some of the most common inflammatory diseases are:
- Crohn’s disease
- Multiple sclerosis
- Amyotrophic lateral sclerosis (ALS)
- Rheumatoid arthritis
- Psoriatic arthritis
- Temporomandibular disorders (TMD)
A study entitled “Cannabidiol, cannabinol, and their combinations act as peripheral analgesics in a rat model of myofascial pain” concluded that the effects of CBN could help people with myofascial pain syndrome. When CBN binds to CB1 receptors, it can decrease the transmission of pain signals. This makes the pain feel less intense and more manageable, especially for those with muscle, joint, and bone discomfort.
CBN for Neuroinflammation
Neuroinflammation can occur within the brain and nervous system. When the brain detects injury or threats, it triggers an inflammatory response that, if excessive, can negatively impact brain function and contribute to the progression of neurological issues.
Chronic neuroinflammation can cause damage to the neurons responsible for transmitting information in the brain. This can lead to cognitive impairment that might contribute to the development of Parkinson’s disease and Alzheimer’s disease.
Research suggests that cannabinoids have neuroprotective properties. These neuroprotective effects indicate its ability to protect neurons from damage and mitigate neuroinflammation. Activation of the cannabinoid receptors by CBN can suppress proinflammatory molecules and regulate immune responses to reduce the intensity of inflammation.
CBN for Inflammatory-Related Anxiety
People who experience chronic inflammation often struggle with their mental health. Inflammatory processes activate the body’s stress responses, which lead to the release of stress hormones like cortisol. Cortisol regulates metabolism, immune response, and blood pressure in response to stress. Prolonged elevated levels of cortisol due to chronic inflammation can increase anxiety.
Inflammation can also disrupt neurotransmitters like serotonin and dopamine. Serotonin regulates mood, appetite, and sleep. Dopamine regulates motivation and reward processing in the brain. Disrupting the balance of these neurotransmitters can lead to anxiety.
CBN benefits anxiety through the CB1 receptors in the ECS, modulating the activity of serotonin and dopamine, and regulating mood and emotional processing. The potential benefits of CBN’s anxiolytic properties make it useful for those who might feel an increase in anxiety symptoms due to inflammation.
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Some research suggests that taking multiple cannabinoids together could be the best way to improve your anxiety. This scientific hypothesis is known as the entourage effect, which proposes that cannabis compounds have a natural synergy with one another. This synergy offers a more well-rounded, whole-plant medicinal experience.
Though research about whether the entourage effect is real or not still needs additional information and studies, it shows promise as a valid theory. The entourage effect is not something one can feel, but refers to the longer-term benefits of using CBN, CBD, and THC together. Many people choose to microdose edibles for anxiety with low doses of tetrahydrocannabinol (THC).
Plus, THC has anti-inflammatory properties, too. Many people choose to microdose THC for pain and inflammation because it allows them to reap the benefits of THC without experiencing the psychoactive effects associated with the cannabinoid. CBD is also known to downregulate THC, making it a more tolerable substance.
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CBN for Inflammatory-Related Sleep Disturbances
Inflammation impacts sleep patterns and your quality of rest, which affects your overall health and wellness. Pain and discomfort may make it challenging to transition the body to rest mode, and certain positions may make inflammation worse.
Inflammation can also disrupt the body’s natural circadian rhythms, the internal clock that regulates your sleep-wake cycle. Inflammatory molecules known as cytokines might interfere with the production and release of melatonin, a key sleep component. Melatonin is a naturally occurring hormone that promotes drowsiness at night.
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CBN’s health benefits include its sedative effects, helping people combat insomnia and other sleep-related issues. Consuming CBN as a sleep aid could calm the body and support an easeful transition into a sleep state.
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CBN for Inflammation-Related Appetite Issues
Inflammation can disrupt your appetite. Cytokines (inflammation-causing molecules) can interfere with signaling pathways involved in hunger. This can cause some people to experience a decrease or increase in appetite, depending on their medical condition.
Inflammation can also disrupt hormones involved in metabolism, making weight management more difficult. Some inflammatory conditions, like rheumatoid arthritis, inflammatory bowel disease, and other autoimmune disorders, can impact appetite and cause changes in eating patterns.
When CBN interacts with the receptors in the ECS, it can regulate your appetite. For those who experience nausea and vomiting due to their condition, CBN can help as an appetite stimulant.
CBN for Cancer-Related Inflammation
Those with cancer must manage inflammation to promote their treatment, care, and overall well-being. Chronic inflammation may create an environment where cancer cells can grow and thrive.
Inflammatory molecules can stimulate the production of factors that support tumor growth. When people with cancer experience chronic inflammation, damage to the healthy tissue surrounding the tumor could occur. These inflammatory molecules might destroy the tissue, causing more pain, progressing tumor growth, and causing cell death.
Research shows cannabinoids have therapeutic benefits for people with cancer. Using CBN could regulate immune responses and tend to inflammation. CBN’s analgesic properties are useful in alleviating pain associated with cancer-related inflammation. People undergoing cancer treatments like chemotherapy could use CBN to subdue nausea and create a more balanced relationship with food. CBN’s pain-relieving properties are useful for those who might experience procedure-related inflammation, like breast cancer surgery.
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