Microdosing cannabis for colorectal cancer

Cannabis has antitumor properties that may be beneficial in the battle against colorectal cancer. A 2021 study suggests that cannabis can inhibit colorectal cancer cell growth and modulate the immune response, boosting the effectiveness of cancer therapy. 

Researchers continue to explore the potential of combining small amounts of cannabis with current immunotherapy approaches to help colorectal patients overcome the resistance of cancer cells to treatment.

If you’re ready to experience the incredible benefits of cannabis without the unwanted side effects, explore our collection of microdosed edibles. Our delicious treats have quickly become the go-to choice for countless cancer patients and others who seek natural relief and therapeutic support.

What is colorectal cancer?

Colorectal cancer, (CRC) or colon cancer, is a type of malignant formation that starts in either the colon (large intestine) or the rectum (the last few inches of the large intestine). It usually begins as a small growth called a polyp on the inner lining of the colon or rectum. Over time, if not removed, some polyps can turn into cancer. 

Colorectal cancer includes two related types of cancer that affect the colon and rectum. Colon cancer begins in the colon, which is the longest part of the large intestine. Rectal cancer starts in the rectum, which is the final section of the large intestine. 

Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. According to the American Cancer Society, CRC is increasingly being diagnosed at younger ages, with 20% of cases in 2023 occurring in people under 55 years old, compared to just 11% in 1995. The proportion of advanced-stage diagnoses has also risen, from 52% in the mid-2000s to 60% in 2019.

What are the symptoms of colorectal cancer?

In the early stages, colorectal cancer often has no symptoms. Some people may experience changes in their bodies that could be signs of the disease. As cancer grows, some common signs and symptoms may include:

1. Changes in bowel habits (diarrhea, constipation, or narrow stools) lasting more than a few days
2. Feeling like you need to have a bowel movement right after you’ve just had one
3. Rectal bleeding or blood in the stool
4. Abdominal pain, cramps, or bloating
5. Vomiting 
6. Weakness and fatigue
7. Unintended weight loss

These symptoms can sometimes be similar to those of other, less serious conditions, making it difficult to recognize the presence of colon cancer. The key to discovering colon cancer early is regular screening. This can also increase the chances of a successful treatment. 

What causes colorectal cancer?

Like all cancers, colon cancer develops when cells in the body grow and divide uncontrollably. The exact causes of colon cancer are not fully understood, but several risk factors such as lifestyle choices and medical conditions may increase a person's likelihood of developing the disease.

• Lifestyle choices:
• Heavy tobacco use
• Excessive alcohol consumption
• Being overweight or obese
• A diet high in red and processed meats
• Lack of physical activity
• Certain medical conditions:
• Inflammatory bowel diseases (e.g., ulcerative colitis and Crohn's disease)
• Inherited conditions (e.g., Lynch syndrome and familial adenomatous polyposis)
• Personal history of numerous colon polyps
• Family history of colon cancer or advanced polyps

How is colorectal cancer treated?

Treatment for colorectal cancer depends on the stage and location of the cancer, as well as the patient's overall health. Here are some common treatment options for CRC:

• Surgery is the primary treatment for early-stage colorectal cancer. This treatment removes the cancerous part of the colon or rectum and nearby lymph nodes.
• Chemotherapy drugs are used to kill cancer cells. Doctors often recommend chemo after surgery for advanced cases or before surgery to shrink large tumors.
• Radiation therapy involves high-energy beams used to kill cancer cells in a specific area. This method is more common for rectal cancer.
• Targeted therapy targets specific proteins or genes involved in cancer growth.
• Immunotherapy helps the body's immune system fight cancer cells. 

In some cases, doctors prescribe a combination of these treatments for a more successful outcome. Many of these treatments can come with a whole bunch of unpleasant side effects that take a toll on a patient's quality of life. 

It's no wonder that a growing number of people are looking into safer, more natural alternatives—such as microdosing cannabis— to help manage their symptoms and support the body's fight against cancer.

Can cannabis help treat colorectal cancer?

Cannabis contains compounds called cannabinoids that can interact with your body's endocannabinoid system (ECS). This system helps regulate important physiological functions, including cell growth and survival. The cannabinoids found in cannabis mimic the effects of your body’s endocannabinoids (molecules that keep our cells in balance), so they are called exocannabinoids. 

By interacting with the endocannabinoid system, cannabis can potentially slow down or stop the growth of colorectal cancer cells. Italian researchers found that endocannabinoids anandamide and 2-AG and their receptors (CB1 and CB2) are present in colorectal cancer tissues and cell lines. Endocannabinoid levels were significantly higher in adenomas and carcinomas compared to normal mucosa. Anandamide, 2-AG, and synthetic cannabinoid agonists potently inhibit the proliferation of colorectal cancer cell lines, primarily by activating CB1 receptors. 

Compounds that prevent the breakdown of the body's own cannabinoids—such as exocannabinoids—can boost their levels in cancer cells, stopping cell growth and increasing the effectiveness of traditional cancer treatments. 

Previous studies suggest that cannabinoids may enhance the effects of immunotherapy and boost the patient's immune system to fight the tumor.

Cannabinoids were shown to modulate the pathways involved in cell proliferation, angiogenesis, programmed cell death and metastasis. Because of that, they are proposed as adjunct therapy for many malignancies.

Cannabis contains two main compounds: THC and CBD. Tetrahydrocannabinol (THC) was shown to kill colorectal cancer cells mainly by activating CB1 receptors. In some animal studies, cannabidiol (CBD) had promising anti-cancer effects in colorectal cancer models.

CBD was also demonstrated to have the antiproliferative effects in colorectal cancer models. In some in vitro studies, CBD protected DNA from oxidative stress, elevated the levels of endocannabinoids, and suppressed colorectal cancer cell proliferation via CB1, TRPV1, PPAR-γ receptors. (Silva-Reis, et. al.)

Researchers from the Penn State College of Medicine found that ten different cannabis compounds were able to kill or reduce the growth of human colon cancer cells. Interestingly, these compounds seemed to work through a different pathway than the usual cannabinoid receptors, suggesting they might fight cancer in a novel way that we don't fully understand yet.

What we do understand is that cannabis can be a versatile ally in fighting colorectal cancer. Its plethora of medicinal and therapeutic benefits can alleviate chronic pain, improve sleep and appetite, soothe inflammatory conditions in the body, and much more. 

The best way to tap into that power is with our delicious THC edibles. Experience the full potential of cannabis with our Euphoria gummies—they deliver just 10 milligrams of THC and CBD for ultimate relief and mild euphoria. 

"Absolutely love this blend. Super uplifting and not too heavy feeling. Will be buying again monthly."

—Lizz

Cannabinoids and cancer: antitumor strategy

More studies are trying to shed light on the incredible antitumor potential of cannabinoids to combat colorectal and other deadly cancer types. Hinz and Ramer showed that THC and CBD can inhibit tumor progression through several mechanisms. Here’s what they found:

1. Cannabinoids can trigger a process called apoptosis. Apoptosis is programmed cell death the body removes damaged, dysfunctional, or unnecessary cells in a controlled manner. THC and CBD target and eliminate cancer cells while leaving healthy cells unharmed. This helps shrink tumors and slow the progression of the disease.
2. Cancer cells are known for their ability to multiply rapidly and uncontrollably. Certain cannabis compounds may inhibit this process by inducing cell cycle arrest, inhibiting the Akt signaling pathway, and reducing the expression of proliferation-promoting proteins.
3. Chronic inflammation is a key player in the development and progression of many cancers, including colorectal cancer. Cannabis has potent anti-inflammatory effects. Hinz and Ramer conclude that “cannabinoids, such as THC and CBD, cause the downregulation of pro-inflammatory cytokines and the upregulation of anti-inflammatory cytokines.” By doing this, they actively suppress the inflammation process. which may help to create a less hospitable environment for cancer cells to thrive.
4. Among other things, the endocannabinoid system is involved in regulating the immune response. Cannabis interacts with the ECS, influencing immune cells and their function to boost the body's natural defenses against cancer.

While researchers are still looking into the anti-cancer potential of cannabis compounds, there is no doubt that THC and CBD can be powerful allies in alleviating the harsh side effects of traditional cancer treatments. 

Cannabis and cancer treatment 

Cannabis may be combined with standard cancer therapies to improve disease outcomes. Some studies suggest that they may aid in sensitizing cancer cells to treatments such as radiation, immunotherapy, and chemotherapy, making them more effective at killing tumors. A large number of patients with cancer turn to cannabis to alleviate cancer treatment side effects. 

Let’s explain. 

1. Zaiachuk, et. al. propose Cannabis sativa extracts as an adjunct therapy for malignancies. They can modulate the immune system, increase tumor immunogenicity, and sensitize cancer cells to other treatments such as immunotherapy. The study authors suggest two possible mechanisms:
2. THC and CBD can increase tumor immunogenicity, so the immune system can better recognize and attack the cancer cells.
3. They may be able to reverse tumor-induced immunosuppression by reprogramming immune cells such as macrophages into an anti-tumor phenotype.
4. According to Cancer Research UK, cannabinoids could help manage common and difficult cancer symptoms like nausea, appetite loss, and pain because of the way they interact with the endocannabinoid system (they resemble our natural endocannabinoids). 
5. Canadian researchers found that cannabis-based medication such as dronabinol, nabilone, and nabiximols may alleviate “many debilitating side effects, including loss of appetite, nausea, insomnia, and anxiety.” A higher number of participants reported at least a 30% reduction in neuropathic pain with cannabinoids compared to placebo, showing how cannabis can significantly improve cancer-associated pain.
6. THC stimulates appetite in patients with cancer. Research reveals that THC and CBD “have indications as appetite stimulants, antiemetics, cannabis addiction, sleep apnea and analgesics and are approved by the FDA for HIV/AIDS-induced weight loss of appetite and chemotherapy-induced nausea and vomiting.” 
7. Cannabis alleviates nausea and vomiting. The cytotoxic chemotherapy drugs designed to kill cancer cells also damage healthy, fast-dividing cells in the body, such as those in the gut, triggering nausea and vomiting. A 2020 clinical trial found that “the addition of oral THC:CBD to standard antiemetics was associated with less nausea and vomiting.” 

Combinations of THC and CBD seem to show enhanced anti-cancer action over either cannabinoid alone. This is the so-called entourage effect: a cannabis synergy in which compounds in the cannabis plant work better together than any single compound alone.

In the entourage effect, cannabinoids such as THC and CBD and other cannabis compounds (terpenes, flavonoids, etc.) work together in harmony. This synergy unlocks therapeutic benefits for treating cancer, alleviating chronic pain and migraines, inducing relaxation, and reducing stress—all while keeping you below the psychoactive threshold. Our low-dose full-spectrum CBD gummies provide the perfect gentle lift without intoxication. 

With our Energy gummies that pack 2.5 mg of THC and 5 mg of CBD per edible, you can find relief from those nasty cancer therapy side effects. Discover why these entourage effect edibles make the ultimate cannabis companion for elevated wellness.

"The energy gummies are great. I have energy and am more motivated. I am a beginner so I take a half and it works great for me. I feel focused and not high at all."

—Lindsey H.

What do colorectal cancer survivors say about microdosing cannabis?

Colon cancer patients are finding hope in the beneficial effects of cannabinoids. Many report that small amounts of THC, CBD, and other cannabis compounds have helped them manage cancer symptoms and chemotherapy side effects. 

According to the Colorectal Cancer Alliance, patients with cancer have used several types of THC-containing products to reduce nausea, chronic pain, and anxiety without the adverse effects often associated with traditional pain medications. 

“As a patient and now a NED survivor, I researched and discovered real help with small bites of THC edible gummies to deal with side effects like nausea after treatment, peripheral neuropathy pain, and general anxiety. It also helped me with deeper, more healing sleep,” said Howard, a stage IV colon cancer survivor. 

Michelle, a stage IV colon and rectal cancer survivor shared a similar experience: “The pain that cancer causes patients can be unbearable… I chose to try edibles and tinctures. They helped alleviate my pain, nausea, and reduced some of my inflammation… THC worked wonders for me and I would choose it again.”

Sonia, a stage III-C rectal cancer survivor, said: “I tried THC candy and liquid drops during chemo and radiation to help with my pain and nausea. It wasn’t high doses, but enough to make a difference.” 

While more research is needed to fully understand the potential of cannabinoids in treating colorectal cancer, these anecdotes suggest that microdosing cannabis may complement other treatments to support the battle against cancer and improve quality of life.

While smoking remains the quickest and easiest way to consume cannabis, these cancer survivors are exploring alternative cannabis consumption methods. Let’s see which method is the best (and why it is our microdosed gummies). 

What is the best way to consume cannabis?

Cannabis consumption has become increasingly popular, not just for recreational purposes but also for its potential therapeutic benefits. There are many different methods of consumption, but not all of them are reliable and safe. The best way to consume cannabis—especially for cancer patients—is with low-dose gummies and cannabis drinks. 

Here are some reasons why:

• Low-dose gummies and drinks make it super easy to control your dosage precisely. With other consumption methods, it's tough to know exactly how much you're getting, but pre-dosed gummies and drinks take all the guesswork out. Here’s our guide to how much Delta 9 is in our gummies.
• Gummies or drinks offer a discreet and convenient way to consume cannabis. It’s much easier for cancer patients to incorporate them into their daily routines without drawing unwanted attention. Pop a gummy in your mouth or craft a delicious and easy THC mocktail, and you’re good to go.
• Edibles and drinkables are metabolized differently than other consumption methods, which results in longer-lasting effects. The effects of gummies can last up to eight hours, while THC drinks can keep you buzzed up to four. These longer-lasting effects of cannabinoids are beneficial for cancer patients who deal with chronic symptoms as they offer extended relief. 
• Smoking or vaping cannabis can irritate the lungs and respiratory system. This may be particularly problematic for cancer patients with compromised respiratory health. Gummies and drinks eliminate this concern.

If you’re feeling like mixing up some flavor, our cannabis drops play nicely with fruity mocktails or herbal lemonades. Explore our collection of drink recipes that blend the benefits of THC, CBD, and your own creative spice. 

Try our buzzy twist on the classic mojito, or delight your palate with our creamy winter mint mocktail. 

Where to buy the best cannabis edibles

You can buy THC edibles at dispensaries in states where recreational marijuana is legal. A much safer choice is to purchase our edibles online anywhere in the country (with the exception of Kansas and Idaho).

Our premium edibles boast carefully selected ingredients, including non-GMO American hemp extract and authentic fruit flavors. Each batch undergoes meticulous third-party lab testing to ensure unparalleled quality and potency, providing you with the confidence that every bite is both safe and pure. 

With our rigorous standards, indulging in our edibles is not just a treat for your taste buds, but also a guarantee of premium quality. Once you go nama™, you never go back. See our guide to where to buy the best cannabis edibles in the country.

Resources

Zaiachuk, M., Pryimak, N., Kovalchuk, O., & Kovalchuk, I. (2021). Cannabinoids, Medical Cannabis, and Colorectal Cancer Immunotherapy. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.713153

Siegel, R. L., Wagle, N. S., Cercek, A., Smith, R. A., & Jemal, A. (2023). Colorectal cancer statistics, 2023. CA: A Cancer Journal for Clinicians, 73(3), 233-254. https://doi.org/10.3322/caac.21772

Ligresti A, Bisogno T, Matias I, De Petrocellis L, Cascio MG, Cosenza V, D'argenio G, Scaglione G, Bifulco M, Sorrentini I, Di Marzo V. Possible endocannabinoid control of colorectal cancer growth. Gastroenterology. 2003 Sep;125(3):677-87. doi: 10.1016/s0016-5085(03)00881-3. PMID: 12949714.

Silva-Reis, R., S. Silva, A. M., Oliveira, P. A., & Cardoso, S. M. (2023). Antitumor Effects of Cannabis sativa Bioactive Compounds on Colorectal Carcinogenesis. Biomolecules, 13(5). https://doi.org/10.3390/biom13050764

Raup-Konsavage WM, Johnson M, Legare CA, Yochum GS, Morgan DJ, Vrana KE. Synthetic Cannabinoid Activity Against Colorectal Cancer Cells. Cannabis Cannabinoid Res. 2018 Dec 21;3(1):272-281. doi: 10.1089/can.2018.0065. PMID: 30671539; PMCID: PMC6340378.

Hinz, B., & Ramer, R. (2022). Cannabinoids as anticancer drugs: Current status of preclinical research. British Journal of Cancer, 127(1), 1-13. https://doi.org/10.1038/s41416-022-01727-4

Zaiachuk, M., Pryimak, N., Kovalchuk, O., & Kovalchuk, I. (2021). Cannabinoids, Medical Cannabis, and Colorectal Cancer Immunotherapy. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.713153

Uk, C. R. (2023, June 21). Cannabis, cannabinoids and cancer – the evidence so far. Cancer Research UK - Cancer News. https://news.cancerresearchuk.org/2022/05/13/cannabis-cannabinoids-and-cancer-the-evidence-so-far/

Cherkasova, V., Wang, B., Gerasymchuk, M., Fiselier, A., Kovalchuk, O., & Kovalchuk, I. (2021). Use of Cannabis and Cannabinoids for Treatment of Cancer. Cancers, 14(20), 5142. https://doi.org/10.3390/cancers14205142

Bilbao, A., & Spanagel, R. (2022, August 19). Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications. BMC Medicine. https://doi.org/10.1186/s12916-022-02459-1

Grimison, P., Mersiades, A., Kirby, A., Lintzeris, N., Morton, R., Haber, P., Olver, I., Walsh, A., McGregor, I., Cheung, Y., Tognela, A., Hahn, C., Briscoe, K., Aghmesheh, M., Fox, P., Abdi, E., Clarke, S., Della-Fiorentina, S., Shannon, J., . . .  Stockler, M. (2020). Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: A randomised, placebo-controlled, phase II crossover trial. Annals of Oncology, 31(11), 1553-1560. https://doi.org/10.1016/j.annonc.2020.07.020

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Silva-Reis, R., S. Silva, A. M., Oliveira, P. A., & Cardoso, S. M. (2023). Antitumor Effects of Cannabis sativa Bioactive Compounds on Colorectal Carcinogenesis. Biomolecules, 13(5). https://doi.org/10.3390/biom13050764

Schmit SL, Rennert HS, Rennert G, Gruber SB. Coffee Consumption and the Risk of Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):634-9. doi: 10.1158/1055-9965.EPI-15-0924. PMID: 27196095; PMCID: PMC4874555.

Mizoguchi, E., Sadanaga, T., Okada, T., Minagawa, T., & Akiba, J. (2023). Does caffeine have a double-edged sword role in inflammation and carcinogenesis in the colon? Intestinal Research, 21(3), 306-317. https://doi.org/10.5217/ir.2022.00118

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