Should you take CBD for menopause?

Menopause causes hot flashes, insomnia, anxiety, joint pain, mood swings, and more. Medical treatments, like hormone replacement therapy or antidepressants, are somewhat effective, but they don’t target symptoms at the source. And they can cause serious side effects that many women want to avoid.

Research points to CBD as a multi-symptom solution that works through your endocannabinoid system, which naturally weakens during menopause. While research is ongoing and limited, the evidence shows CBD can target menopause symptoms. A 2022 survey of perimenopausal and postmenopausal women found that women who use medical cannabis report significant improvements in sleep, anxiety, and overall quality of life.

Experience the benefits of CBD for menopause and perimenopause with nama™ CBD edibles.

How does CBD affect menopause symptoms?

The endocannabinoid system (ECS) regulates everything menopause disrupts:

• Temperature control
• Mood
• Sleep
• Bone density
• Inflammation

Research shows estrogen directly influences ECS function. When estrogen plummets during menopause, your endocannabinoid signaling goes haywire. CBD can enhance your body's natural cannabinoids and activate receptors that estrogen normally stimulates.

Another study shows that CBD interacts with estrogen signaling pathways. This potentially explains why it addresses so many menopausal symptoms. CBD doesn't replace estrogen; it improves the systems that are estrogen-deprived. It binds to TRPV1 receptors, which control body temperature, and 5-HT1A receptors, which regulate mood and anxiety. It also reduces the inflammatory markers that spike during menopause.

CBD and menopause research

A 2022 survey contains the most compelling evidence for CBD as a menopause treatment. Among 258 perimenopausal and postmenopausal participants, medical cannabis users reported improvements across multiple symptoms. Sleep quality showed the most dramatic improvement, followed by anxiety and mood stabilization.

A 2023 systematic review examined CBD's effects on menopausal women's health. The researchers found consistent benefits for anxiety, sleep, and pain. The review noted CBD's favorable safety profile compared to hormone therapy and conventional medications.

Laboratory studies provide mechanistic support. A 2022 Frontlines review details how cannabinoids influence bone metabolism to potentially protect against menopause-related osteoporosis. Animal models show that CBD preserves bone density and reduces fracture risk.

While large-scale clinical trials focused on menopause are still needed, existing evidence demonstrates that CBD can help manage menopause symptoms. Every study notes CBD's excellent safety profile, with minimal side effects compared to conventional menopause treatments.

Which menopause symptoms does CBD improve?

Sleep disturbances and insomnia

Up to 60% of menopausal women battle insomnia, and CBD emerges as a powerful sleep aid without the hangover effect of prescription medications. Studies show CBD increases total sleep time and reduces nighttime awakening. The mechanism involves CBD's action on adenosine receptors and its ability to reduce cortisol, the stress hormone that keeps you wired at 3 AM.

Anxiety and mood swings

CBD shines brightest for menopause-related anxiety. Clinical trials demonstrate CBD's anxiolytic effects occur through serotonin receptor activation, GABAergic modulation, and reduced activity in the amygdala (fear center).

Joint pain and inflammation

Menopause accelerates joint degeneration and inflammatory conditions. A 2019 study found that CBD reduces inflammatory cytokines and provides analgesic effects through multiple pathways. The anti-inflammatory action helps women who suffer from menopause-related arthritis, with users reporting improved mobility and reduced morning stiffness.

Does taking CBD for menopause carry any risks?

CBD has an exceptional research-backed safety profile, though long-term effects are still a topic of research. Side effects are mild and uncommon: dry mouth, slight drowsiness, and occasional digestive changes (such as an increase in appetite). These typically resolve within days as your body adjusts.

CBD can affect how your liver processes certain medications, including:

• Blood thinners (warfarin)
• Heart rhythm medications
• Thyroid hormones
• Some antidepressants

Read about the safety of CBD for seniors.

Best nama CBD products for menopause

We provide our customers with only the very best CBD products that help alleviate pain and discomfort associated with menopause. Because of our team's dedication to the quality of our products and customer satisfaction, our customers have fallen in love with our vegan CBD gummies. Check out their reviews here.

Our Sleep gummies tackle menopause insomnia with surgical precision. Each wild strawberry gummy contains 25 mg CBD for anxiety relief, 5 mg CBN to enhance deep sleep, and 3 mg melatonin to regulate your disrupted circadian rhythm. Women report falling asleep faster and waking refreshed, not groggy like with prescription sleep aids.

For daytime symptom management, try Relax CBD gummies. They deliver 25 mg CBD plus 100 mg ashwagandha per serving. This adaptogenic combination addresses the stress and anxiety that can spike during perimenopause. 

If you’re dealing with menopause-related pain issues, try our Pain Plus gummies. These gummies contain CBD, THC, CBN, CBC, and CBG to attack pain and inflammation from multiple angles.

Whichever product you choose, go slow. Start with a low dose and work your way up until you find your sweet spot.

Shop all nama products.

Resources

Dahlgren, M. K., El-Abboud, C., Lambros, A. M., Sagar, K. A., Smith, R. T., & Gruber, S. A. (2022). A survey of medical cannabis use during perimenopause and postmenopause. Menopause (New York, N.Y.), 29(9), 1028–1036. https://doi.org/10.1097/GME.0000000000002018

Santoro, A., Mele, E., Marino, M., Viggiano, A., Nori, S. L., & Meccariello, R. (2021). The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery. International journal of molecular sciences, 22(2), 972. https://doi.org/10.3390/ijms22020972

Alves, P., Amaral, C., Fonseca, B. M., Sousa, L. G., Teixeira, N., & Correia-Da-Silva, G. (2025). Effects of cannabidiol, cannabichromene, cannabidivarin, cannabigerol and cannabinol in endometrial cells: Implications for endocrine and senescence modulation. Reproductive Toxicology, 137, 109006. https://doi.org/10.1016/j.reprotox.2025.109006

Babyn, K., Ross, S., Makowsky, M., Kiang, T., & Yuksel, N. (2023). Cannabis use for menopause in women aged 35 and over: a cross-sectional survey on usage patterns and perceptions in Alberta, Canada. BMJ open, 13(6), e069197. https://doi.org/10.1136/bmjopen-2022-069197

Sui, K., Tveter, K. M., Bawagan, F. G., Buckendahl, P., Martinez, S. A., Jaffri, Z. H., MacDonell, A. T., Wu, Y., Duran, R. M., Shapses, S. A., & Roopchand, D. E. (2022). Cannabidiol-Treated ovariectomized mice show improved glucose, energy, and bone metabolism with a bloom in lactobacillus. Frontiers in Pharmacology, 13, 900667. https://doi.org/10.3389/fphar.2022.900667

Kisiolek, J. N., Flores, V. A., Ramani, A., Butler, B., Haughian, J. M., & Stewart, L. K. (2023). Eight weeks of daily cannabidiol supplementation improves sleep quality and immune cell cytotoxicity. Nutrients, 15(19), 4173. https://doi.org/10.3390/nu15194173

Wright, M., Di Ciano, P., & Brands, B. (2020). Use of Cannabidiol for the Treatment of Anxiety: A Short Synthesis of Pre-Clinical and Clinical Evidence. Cannabis and cannabinoid research, 5(3), 191–196. https://doi.org/10.1089/can.2019.0052

Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants (Basel, Switzerland), 9(1), 21. https://doi.org/10.3390/antiox9010021 

Further reading

CBD for stress and anxiety management

What are the best CBD gummies for menopause?

What is the best weed strain for anxiety?

Should you microdose cannabis for menopause?

Does CBN help ease anxiety?

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