Does CBG relieve pain?

Cannabigerol (CBG) blocks pain signals and soothes the inflammation that feeds chronic discomfort. This minor cannabinoid doesn't build tolerance, like prescription painkillers, and it maintains effectiveness with regular use while keeping your mind clear.

As part of the entourage effect, CBG amplifies the pain-fighting abilities of other cannabis compounds. We created Pain Plus gummies to combine microdoses of CBG with four additional cannabinoids in a precise formula that targets multiple pain pathways for relief you can feel.

How does CBG make you feel?

Like other cannabis compounds, CBG works through your endocannabinoid system (ECS) to influence sleep, stress, and pain. It doesn’t bind strongly to CB1 receptors in your brain, which means you get therapeutic benefits without psychoactive effects.

People who use CBG for pain typically experience:

• Pain relief without mental fog. 
• Reduced muscle tension and joint stiffness. 
• A subtle mood boost that feels natural, not artificial. 
• Physical relaxation while staying mentally sharp. 
• Better focus once pain stops hijacking your attention. 
• Smoother movement throughout the day. 
• Relief that feels like your body's natural response.

The pain-relieving properties of CBG

CBG targets pain perception through multiple receptor pathways. A 2024 study found that it activates receptors that naturally reduce pain signal transmission in your nervous system. The cannabinoid also initially triggers pain receptors but then desensitizes them, shutting down the pain pathway after activation.

Research by Sepulveda, et. al. demonstrated that CBG reduced nerve pain sensitivity in mice treated with chemotherapy drugs. In their study, CBG targeted several types of pain receptors to block pain signals. 

CBG also prevents the breakdown of anandamide, your body's natural pain-fighting compound, allowing it to stay active longer. The cannabinoid achieves pain relief without causing the drowsiness or cognitive impairment common with prescription painkillers.

How does CBG fight inflammation?

Inflammation drives most chronic pain conditions. Kogan and her team reveal how CBG targets different inflammatory pathways to provide comprehensive relief.

• CBG blocks inflammatory messengers by suppressing cytokines (pro-inflammatory molecules) that signal pain responses throughout your body. This prevents the inflammatory cascade that amplifies pain and tissue damage.
• CBG reduces nitric oxide production in immune cells and decreases inflammatory enzyme activity, targeting the inducible nitric oxide synthase (iNOS) that drives inflammatory responses.
• It activates PPARγ receptors to maintain cellular balance between oxidants and antioxidants while inhibiting enzymes that create inflammatory compounds.
• CBG protects brain cells by inhibiting microglial activation, which contributes to neurodegeneration in conditions such as multiple sclerosis. It reduces cytokine and nitric oxide production in neural tissue.
• CBG blocks NF-κB signaling, the master regulator of inflammation, by increasing protective IκB-α levels. At the same time, it lowers nuclear NF-κB activity that would trigger inflammatory gene expression.

CBG's anti-inflammatory effects surpass many synthetic drugs without harsh side effects on your digestive system or kidneys. The cannabinoid works with your body's natural chemistry to complement anti-inflammatory medications.

Our Pain Plus gummies harness this power by combining CBG with CBC, CBD, THC, and CBN in a targeted five-cannabinoid blend that tackles inflammation and pain. The precise microdosed amounts in each gummy provide consistent pain relief without overwhelming your system, allowing you to maintain therapeutic levels of analgesic cannabinoids throughout the day.

CBG dosage for pain relief

Microdosing CBG maximizes therapeutic potential while minimizing adverse effects. Start with 2.5–5 mg and see how you respond. Some people need more for stubborn neuropathic pain or inflammatory conditions, while others get relief with less. CBG's analgesic properties don't fade over time like opioids, so you don’t need to re-up your dose.

Keep your dosing schedule consistent to maintain steady cannabinoid levels. Take CBG with food for better absorption and less stomach irritation. Fatty food helps this cannabinoid work more effectively.

When to take CBG

CBG won't knock you out or create mind-altering effects, so daytime use is fine for most people. Morning doses prevent pain from hijacking your day, and the effects of CBG edibles can last about 6 hours. Evening doses stop inflammatory pain from messing with your sleep. CBG won't make you drowsy, but effective pain relief helps you rest better.

You can also take CBG 30–60 minutes before exercise to prevent flare-ups. Its anti-inflammatory and analgesic properties work through cannabinoid receptors to block exercise-induced discomfort.

Stick to regular schedules instead of waiting for pain to get unbearable. Steady levels beat sporadic dosing for medical conditions and inflammatory diseases. 

What are the side effects of CBG?

CBG has an excellent safety profile with minimal adverse effects. Most people tolerate this cannabinoid, even for neurological conditions or other medical conditions.

Higher CBG doses may cause:

• Dry mouth.
• Mild fatigue.
• Slight appetite changes.
• Temporary digestive discomfort.
• Possible medication interactions.
• Lightheadedness when standing quickly.

Most side effects disappear as your body adjusts to regular CBG use. CBG doesn't damage your liver, kidneys, or create addiction. Get medical advice if you take prescription medications because CBG may affect how your liver processes certain drugs. This non-psychoactive cannabinoid won't cause physical dependence or withdrawal symptoms. 

What are the best CBG gummies for pain relief?

Pain Plus gummies deliver comprehensive relief through a five-cannabinoid formula that targets different forms of pain from every angle. Each tangerine-flavored gummy contains 5 mg CBG from the cannabis plant alongside 10 mg CBC, 10 mg CBD, 10 mg THC, and 5 mg CBN.

This multi-cannabinoid approach leverages the entourage effect, where cannabinoids amplify each other's therapeutic effects. CBG's anti-inflammatory properties combine with CBC's pain-blocking abilities, CBD's anxiety relief, THC's analgesic effects, and CBN's muscle relaxation to provide therapeutic benefits that single compounds can't match.

If you’re looking to relieve stress-related pain, Relax Plus gummies melt away tension with 5 mg THC and 25 mg CBD in refreshing watermelon flavor. The combination targets physical discomfort and the stress that amplifies pain sensation.

When you need everyday comfort without the heaviness, our Bliss Delta 9 gummies hit the sweet spot with equal parts THC and CBD (5 mg each) in delicious melon flavor. These work well for moderate pain while maintaining mental clarity and supporting normal physiological processes.

All our edibles undergo rigorous third-party testing for potency and purity. Made from premium American hemp with no artificial additives, our vegan, gluten-free gummies provide consistent, reliable pain relief.

Get nama gummies and discover what real pain relief feels like.

Resources

Li S, Li W, Malhi NK, Huang J, Li Q, Zhou Z, Wang R, Peng J, Yin T, Wang H. Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential. Molecules. 2024 Nov 20;29(22):5471. doi: 10.3390/molecules29225471. PMID: 39598860; PMCID: PMC11597810.

Sepulveda DE, Morris DP, Raup-Konsavage WM, Sun D, Vrana KE, Graziane NM. Cannabigerol (CBG) attenuates mechanical hypersensitivity elicited by chemotherapy-induced peripheral neuropathy. Eur J Pain. 2022 Oct;26(9):1950-1966. doi: 10.1002/ejp.2016. Epub 2022 Aug 4. PMID: 35899583.

Kogan NM, Lavi Y, Topping LM, Williams RO, McCann FE, Yekhtin Z, Feldmann M, Gallily R, Mechoulam R. Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity. Molecules. 2021 Sep 15;26(18):5601. doi: 10.3390/molecules26185601. PMID: 34577072; PMCID: PMC8467477.

Further reading

Best Delta 9 gummies to relieve pain

Why is hybrid cannabis better for pain relief?

Best CBD for joint pain relief

Best sciatica-fighting edibles

Why is CBN good for soothing chronic pain?

Explore pain-relieving terpenes

How does CBN help with nerve pain

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